γ-amino-β-ketosulfones as chiral educts: A facile synthesis of enantiopure α-amino ketones

Article abstract of DOI:10.1016/S0040-4020(98)00533-X

Starting from 'chiral-pool' derived γ-amino-β-ketosulfones, a facile synthesis of enantio-pure α-amino ketones has been developed via an α- alkylation-desulfonation sequence. Extension of this methodology to enantiopure α-acetoxy ketone synthesis, however, have met with limited success.