Novel and general entry into pseudoguaianolides. Formal and enantioselective synthesis of (+)-confertin

Article abstract of DOI:10.1016/S0040-4039(98)01180-0

A novel and general access to pseudoguaianolide sesquiterpenoids has been developed by employing a diastereoselective acyl radical-mediated 7- endo-trigonal mode of cyclization as a key reaction step. The methodology has successfully been applied to the formal enantioselective synthesis of (+)- confertin.