Synthesis of 4-trifluoromethyl-1,2,4-trioxanes, simplified analogues of Artemisinin

DOI: 10.1016/S0022-1139(98)00226-7

Source and publish data:

Journal of Fluorine Chemistry p. 199 - 201 (1998)

Update date:2022-08-03

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Authors:

Provot, Olivier

Moskowitz, Henri

Mayrargue, Joelle

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Article abstract of DOI:10.1016/S0022-1139(98)00226-7

A short synthesis of C₄ trifluoro-substituted 1,2,4-trioxanes with antimalarial potential is reported. This is the first example using a trifluorosilylated enol ether function as a protective group for a trifluoromethyl carbonyl.

Full text of DOI:10.1016/S0022-1139(98)00226-7

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