Synthesis of 4-trifluoromethyl-1,2,4-trioxanes, simplified analogues of Artemisinin

DOI: 10.1016/S0022-1139(98)00226-7

Source and publish data:

Journal of Fluorine Chemistry p. 199 - 201 (1998)

Update date:2022-08-03

Topics:

Authors:

Provot, Olivier

Moskowitz, Henri

Mayrargue, Joelle

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0022-1139(98)00226-7

A short synthesis of C₄ trifluoro-substituted 1,2,4-trioxanes with antimalarial potential is reported. This is the first example using a trifluorosilylated enol ether function as a protective group for a trifluoromethyl carbonyl.

Full text of DOI:10.1016/S0022-1139(98)00226-7

Products guided by the article

Product name:4-<2-(Methoxymethylidene)cyclohexyl>-1,1,1-trifluorobutan-2-one

Cas No:218130-51-9

R&D Labs maybe for 218130-51-9

MS( MAOSHENG )Chemical CO.,LTD

Contact:+86-519-82726678.82726378

Address:TAOXI INDUSTRY ZONE JINTAN
Wuhan Shangrisyn chemicals Technology Co.,Ltd(expird)

Contact:+86-027-84466317 __ +86-15387123698

Address:wuhan - china
Zhejiang Chemline International Co., Ltd.

Contact:+86-571-88062298

Address:Hengdian Industry Area, Dongyang, Zhejiang, China
Hebei Think-Do Environment Co., Ltd

website:http://www.thinkdo-environment.com

Contact:0311-86510809-

Address:No 6, Shilian Middle Street, Circular Chemical Industry Park
Jingzhou TianHe Sci&Tech Chemical Co., Ltd.

Contact:86-716-8331612

Address:Jiangjin Road, #18, High-grade technology industries development district, Jingzhou city, Hubei province

Relevant to this article

Synthetic study on a 26-membered macrolide, amphidinolide B: Synthesis of the C₁-C₁₃ fragment

Doi:10.1246/bcsj.71.2433
(1998)
Determining the σ-donor ability of the cyclopropane C-C bond

Doi:10.1039/b503124a
(2005)
Anion Recognition by Neutral Chalcogen Bonding Receptors: Experimental and Theoretical Investigations

Doi:10.1002/chem.201905786
(2020)
Exploration of β-turn scaffolding motifs as components of sialyl Le(x) mimetics and their relevance to P-selectin

Doi:10.1016/S0960-894X(98)00500-9
(1998)
Nonpeptide somatostatin agonists with sst₄ selectivity: Synthesis and structure-activity relationships of thioureas

Doi:10.1021/jm980118e
(1998)
Synthesis of dimeric Lewis X antigenic determinant with azido-type spacer arm by a sequence of regioselective glycosylation steps

Doi:10.1016/S0040-4039(98)02104-2
(1998)

Article Doi