Tetrahedron Asymmetry p. 3731 - 3735 (1998)
Update date:2022-09-26
Topics:
Bravo, Pierfrancesco
Corradi, Eleonora
Pesenti, Cristina
Vergani, Barbara
Viani, Fiorenza
Volonterio, Alessandro
Zanda, Matteo
Two efficient approaches to both enantiomers of syn-γ-trifluoromethyl γ-amino β-hydroxy butyric acid (γ-Tfm-GABOB) (10), a new hydroxymethylene (statine) dipeptide isostere, are described. One exploits the recently disclosed 'non-oxidative' Pummerer reaction, by means of which α-lithium alkyl sulfoxides are used as chiral α-hydroxyalkyl anion equivalents in the synthesis of β-amino alcohols. Trifluoropyruvaldehyde-N,S-ketal (R)-11, a novel stereochemically stable synthetic equivalent of α-amino trifluoropropanal, is used in the second approach.
View MoreWuxi Highness Chemical Co.,Ltd
website:https://www.phtpharmatech.com/
Contact:86-510-81771080
Address:No58 East Xinguan Rd, Guanlin Town, Yixing City, Jiangsu China
shijiazhuang alkay chemicals co..ltd(expird)
Contact:86-311-67692035
Address:2601,juntang building,qiaodong district,shijiazhuang
guide(suzhou) fine materials co. ltd
Contact:0512-80972173
Address:21st Building, No.369 Lushan Rd, New District Suzhou China 215129
FREEBARQUE DEVELOPMENT GROUP LIMITED
Contact:+86(0)10-5109 5335 or 5109 5345
Address:Room602,Block1-B,LINGDI OFFICE,NO.13 BEIYUAN ROAD
Feis International Trade Co,. Ltd
Contact:13961823444-18235944442
Address:Wuxi jiangsu
Doi:10.1021/ja983153j
(1999)Doi:10.1039/a807736c
(1998)Doi:10.1016/S0277-5387(98)00278-2
(1998)Doi:10.1016/S0040-4020(98)01053-9
(1999)Doi:10.1016/S0040-4020(98)01067-9
(1999)Doi:10.1021/jo00985a013
(1972)