Tetrahedron Letters p. 657 - 660 (1999)
Update date:2022-07-30
Topics:
Ma, Chunrong
Liu, Xiaoxiang
Yu, Shu
Zhao, Shuo
Cook, James M.
A concise synthesis of optically active tryptophan derivatives was developed via diastereoselective alkylation of the Schollkopf chiral auxiliary 4 to provide alkyne 2 which underwent palladium-catalyzed heteroannulation with iodoanilines 1 to furnish protected tryptophans 3. Hydrolysis and subsequent saponification of 3 provided the desired tryptophans 12 in good yields.
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Doi:10.1002/cssc.201903430
(2020)Doi:10.1039/d1tc01825f
(2021)Doi:10.1016/S0960-894X(03)00485-2
(2003)Doi:10.1007/s12272-012-1204-6
(2012)Doi:10.1016/S0040-4039(01)88896-1
(1969)Doi:10.1016/S0008-6215(99)00067-1
(1999)
