First total synthesis of martefragin A, a potent inhibitor of lipid peroxidation isolated from sea alga

DOI: 10.1016/S0040-4039(98)01228-3

Source and publish data:

Tetrahedron Letters p. 5983 - 5986 (1998)

Update date:2022-07-31

Topics:

Authors:

Nishida, Atsushi

Fuwa, Mihoko

Fujikawa, Yukiko

Nakahata, Etsuko

Furuno, Asako

Nakagawa, Masako

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Article abstract of DOI:10.1016/S0040-4039(98)01228-3

The first total synthesis of martefragin A, a potent inhibitor of lipid peroxidation isolated from sea alga, has been accomplished and the absolute configurations of two stereogenic centers were determined. Synthetic martefragin A, its stereo isomers, and some analogs showed strong inhibitory activity against lipid peroxidation rat liver microsome.

Full text of DOI:10.1016/S0040-4039(98)01228-3

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