First total synthesis of martefragin A, a potent inhibitor of lipid peroxidation isolated from sea alga

Article abstract of DOI:10.1016/S0040-4039(98)01228-3

The first total synthesis of martefragin A, a potent inhibitor of lipid peroxidation isolated from sea alga, has been accomplished and the absolute configurations of two stereogenic centers were determined. Synthetic martefragin A, its stereo isomers, and some analogs showed strong inhibitory activity against lipid peroxidation rat liver microsome.