Tetrahedron Asymmetry p. 1733 - 1738 (1999)
Update date:2022-08-04
Topics:
Braga, Antonio L.
Appelt, Helmoz R.
Schneider, Paulo H.
Silveira, Claudio C.
Wessjohann, Ludger A.
A new, easily accessible, chiral disulfide 3 was prepared from L- cysteine in a short synthetic sequence (Scheme 1) and applied successfully as a highly efficient catalyst for the enantioselective addition of diethyl zinc to aromatic and aliphatic aldehydes to afford the product alcohols in up to more than 99% ee. In contrast to the more common amino alcohols used in similar reactions, catalyst 3 does not have a protic hydrogen in the form of a free hydroxy group.
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