Diphenylsilyldiethylene- (DPSide-) group: A new primary amine protection

Article abstract of DOI:10.1016/S0040-4039(99)00970-3

Diphenylsilydiethylene- (DPSide-) group has been developed as a new primary amine protecting group. The new protecting group exhibits novel orthogonality against other commonly used amine-protecting groups and excellent chemoselectivity for unbranched α-amino acid esters. Removal of this protecting group was effected under mild fluoride-based cleavage conditions.