Studies toward the total synthesis of antibiotic roseophilin: A novel synthesis of the macrotricyclic part

Article abstract of DOI:10.1016/S0040-4039(98)01450-6

The macrotricyclic part of roseophilin, a novel cytotoxic antibiotic, was efficiently synthesized starting with the known 3-formylpyrrole; the method features intramolecular alkylation to form the desired thirteen- membered carbocycle and base-induced int