A one-pot and efficient preparation of (S)-benzyl 4-hydroxy-2-pentynoate from (S)-3-butyn-2-ol using an unusual lithiation with n-BuLi and a catalytic amount of hexamethyldisilazane

Article abstract of DOI:10.1080/00397919908086476

A one-pot, four-step procedure was developed for the efficient preparation of (S)-benzyl 4-hydroxy-2-pentynoate (1) from (S)-3-butyn-2-ol (2), which involved as a key step the unusual lithiation of the silyl ether 5 with n-BuLi in the presence of a cataly

Full text of DOI:10.1080/00397919908086476

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Synthetic Communications: An
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A One-Pot and Efficient Preparation
of (S)-Benzyl 4-Hydroxy-2-
Pentynoate from (S)-n-Butyn-2-Ol
Using an Unusual Lithiation with
n-BuLi and a Catalytic Amount of
Hexamethyldisilazane
Gaifa Lai a & Cesar Colon a
a Schering-Plough Research Institute, Chemical Process R &
D , 1011 Morris Avenue, Union, New Jersey, 07083
Published online: 25 Sep 2007.
To cite this article: Gaifa Lai & Cesar Colon (1999) A One-Pot and Efficient Preparation of (S)-
Benzyl 4-Hydroxy-2-Pentynoate from (S)-n-Butyn-2-Ol Using an Unusual Lithiation with n-BuLi
and a Catalytic Amount of Hexamethyldisilazane, Synthetic Communications: An International
Journal for Rapid Communication of Synthetic Organic Chemistry, 29:17, 3011-3016, DOI:
10.1080/00397919908086476
To link to this article: http://dx.doi.org/10.1080/00397919908086476
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