Bioorganic and Medicinal Chemistry Letters p. 2195 - 2198 (1999)
Update date:2022-08-03
Topics:
Fryatt, Tara
Goroski, Dean T.
Nilson, Zachary D.
Moody, Christopher J.
Beall, Howard D.
The effects of functional group changes on the metabolism of novel quinolinequinones by recombinant human NAD(P)H:quinone oxidoreductase (NQO1) are described. Overall, the quinolinequinones were much better substrates for NQO1 than analogous indolequinones, with compounds containing heterocyclic substituents at C-2 being among the best substrates.
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Doi:10.1039/c4cc06739h
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(1999)
