Construction of an enantiomerically pure 6-substituted 3,5-syn-dihydroxyhexanoic acid system by an enantioselective deprotonation strategy: Formal synthesis of an antiobesity agent, (-)-tetrahydrolipstatin

DOI: 10.1248/cpb.48.1545

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Chemical and Pharmaceutical Bulletin p. 1545 - 1548 (2000)

Update date:2022-08-03

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Honda Honda

Endo Endo

Ono Ono

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Article abstract of DOI:10.1248/cpb.48.1545

Preparation of 6-substituted 4-hydroxytetrahydro-2H-pyran-2-one (12), a key intermediate for the synthesis of (-)-tetrahydrolipstatin, was achieved in an optically pure form by employing an enantioselective deprotonation reaction of the prochiral bicyclic

Full text of DOI:10.1248/cpb.48.1545

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