Stereoselective synthesis of (2S,3S)-3-hydroxy-2-phenylpiperidines, precursors of non-peptidic substance P antagonists

Article abstract of DOI:10.1016/S0040-4039(99)01462-8

(2S)-N-Boc-3-oxo-2-phenylpiperidine 5 and (2S,3S)-N-Boc-3-hydroxy-2- phenylpiperidine 6, known chiral building blocks for the synthesis of non- peptidic substance P antagonists, were prepared from erythro (2S)-N-benzyl 2- hydroxybenzylpyrrolidine derived from (S)-N-methoxy-N-methylpyroglutamide.