Synthesis, reactivity and biochemical evaluation of 1,3- substituted azetidin-2-ones as enzyme inhibitors

Article abstract of DOI:10.1016/S0040-4020(99)00819-4

A series of monocyclic azetidinones were prepared, bearing, at position C-3, an acetylamino or a bromo substituent, at position N-1, a carboxymethyl group protected as p-nitrobenzyl ester (PNB) and α-functionalized with a potential leaving group (LG). The