Synthesis of γ-[15N]-L-glutamyl derivatives of 5,10-dideazatetrahydrofolate

Article abstract of DOI:10.1002/(SICI)1099-1344(199911)42:11<1103::AID-JLCR269>3.0.CO;2-E

A synthesis of the mono-, di-, and tri[¹⁵N]glutamate forms of the potent de novo purine synthesis inhibitor and anticancer agent (6R,6S)-5,10-dideaza-5,6,7,8-tetrahydrofolate (6R,6S-DDATHF) from (6R,6S)-5,10-dideaza-5,6,7,8-tetrahydropteroic ac