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Synthesis of benzimidazole derivatives as antiallergic agents with 5- lipoxygenase inhibiting action

DOI: 10.1248/cpb.47.1573

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Chemical and Pharmaceutical Bulletin p. 1573 - 1578 (1999)

Update date:2022-08-03

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Authors:

Nakano, HiroyukiNakano, Hiroyuki

Inoue, TsutomuInoue, Tsutomu

Kawasaki, NobuhideKawasaki, Nobuhide

Miyataka, HidekiMiyataka, Hideki

Matsumoto, HitoshiMatsumoto, Hitoshi

Taguchi, TakeoTaguchi, Takeo

Inagaki, NaokiInagaki, Naoki

Nagai, HiroichiNagai, Hiroichi

Satoh, ToshioSatoh, Toshio

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Article abstract of DOI:10.1248/cpb.47.1573

Syntheses were conducted of novel benzimidazole derivatives that suppress histamine release from mast cells, inhibit 5-lipoxygenase, and possess antioxidative action. Among the compounds synthesized, 1-[2-[2-(4- hydroxy-2,3,5-trimethylphenoxy)ethoxy]ethyl]-2-(4-methyl-1- homopiperazino)benzimidazole (22) potently suppressed histamine release from rat peritoneal mast cells triggered by the antigen-antibody reaction, inhibited 5-lipoxygenase in rat basophilic leukemia-1 (RBL-1) cells, and prevented the NADPH-dependent lipid peroxidation induced by Fe3+-ADP in rat liver microsomes, in addition to an antagonizing the contraction of guinea pig ileum caused by histamine.

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Full text of DOI:10.1248/cpb.47.1573

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Product name:2-chloro-1-[4-(4-hydroxy-2,3,5-trimethylphenoxy)butyl]-1H-benzimidazole

Cas No:256366-70-8

256366-70-8

R&D Labs maybe for 256366-70-8

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