Unusual ring closure reaction of amides with pyrimidines: Novel stereoselective synthesis of hexahydroimidazo[1,2-c]pyrimidines

DOI: 10.1055/s-1999-3640

Source and publish data:

Synthesis p. 2124 - 2130 (1999)

Update date:2022-08-02

Topics: Amides Stereoselective synthesis Pyrimidines

Authors:

Acero-Alarcoì?n, Alberto

Armero-Alarte, Trinidad

Jorda-Gregori, Joan M.

Rojas-Argudo, Cristina

Zaballos-Garciì?a, Elena

Server-Carrioì?, Juan

Ahjyaje, Fatima Z.

Sepulveda-Arques, Joseì?

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1055/s-1999-3640

Hexahydromidazo[1,2-c]pyrimidines 6 were prepared by the reaction of tosylpyrimidines 2 with bromoacetamides 3 in one step. The stereoselectivity of the reaction has been confirmed by X-ray analysis. Imidazo[1,2- a]pyrimidines 5 were obtained on heating h

Full text of DOI:10.1055/s-1999-3640

Products guided by the article

Product name:2-(4-bromo-phenyl)-2-[2-(toluene-4-sulfonylimino)-2H-pyrimidin-1-yl]-acetamide

Cas No:257290-73-6

R&D Labs maybe for 257290-73-6

Hebei DaPeng Pharm & Chem Co., Ltd.

Contact:86-317-7298678,0576-88861898 88861908

Address:West Songmen Village, East Songmen Town, Wuqiao, Cangzhou, Hebei ,China
Hefei Highzone Fine Chemical S&T CO.,LTD

Contact:86-0551-63663560

Address:room 1801 NO. 24 Shuguang RD.
Shanghai Kefu Chemical Co.,Ltd.

Contact:+86-21-34616196

Address:Room601-602, Xuhui Business Building, No.168, Yude Road, Shanghai
Shijiazhuang Sdyano Fine Chemical Co., Ltd

Contact:+86-311-89830448

Address:NO.48 Ta Nan Road,Yuhua District,Shijiazhuang,Hebei,China
Tianjin Bright Future Technology Co., Ltd

Contact:0086-22-58016666

Address:NO.136 DongTeng Lake Street Tianjin Economic and Technology Development Area,Tainjin,China

Relevant to this article

Synthesis and biological evaluation of 1-azabicyclo-[3.2.1]octanes: New dopamine transporter inhibitors

Doi:10.1016/S0960-894X(00)00308-5
(2000)
Radiosynthesis of Carbon-11 labelled N-methyl-2-(arylthio)benzylamines: Potential radiotracers for the serotonin reuptake receptor

Doi:10.1002/(SICI)1099-1344(19991230)42:13<1277::AID-JLCR284>3.0.CO;2-Q
(1999)
Hit-to-Lead studies: The discovery of potent, orally bioavailable thiazolopyrimidine CXCR2 receptor antagonists

Doi:10.1016/j.bmcl.2005.10.091
(2006)
PB-10, a thiazolo[4,5-d] pyrimidine derivative, targets p21-activated kinase 4 in human colorectal cancer cells

Doi:10.1016/j.bmcl.2019.126807
(2020)
Synthesis and evaluation of hydroxylated polyamine analogues as antiproliferatives

Doi:10.1021/jm990375z
(2000)
Catalytic and stoichiometric reactions of tertiary silanes with [Ir(Me)₂Cp*L] (Cp=η⁵-C₅Me₅; L=PMe₃, PMe₂Ph, PMePh₂, PPh₃) in the presence of one-electron oxidants. A unique case of Si-H, Si-C, Ir-C and P-F bonds one-step activation: Crystal structure of [Ir(Ph)(SiPh₂F)Cp*(PMe₃)]

Doi:10.1016/S0022-328X(99)00469-6
(2000)

Article Doi