Synthesis of a New Branched Chain Hexopyranosyl Nucleoside: 1--thymine

Article abstract of DOI:10.1016/S0040-4020(01)80830-9

A straightforward synthesis of the branched chain nucleoside 7 is described.This synthesis involves two stereoselective steps: introduction of the hydroxymethyl group on the sugar is achieved by radical cyclization of the (bromomethyl)dimethylsilyl ether of the allylic alcohol 8; the condensation reaction with thymine as base moiety resulted exclusively in the formation of the α-anomer.