Synthesis of N-aryl substituted 4H-1,4-benzothiazine 1,1-dioxide 2-carboxylic acid-esters

Article abstract of DOI:10.1080/10426509808045484

A group of N-aryl substituted 1,4-benzothiazine-1,1-dioxide-2 carboxylic acid esters is reported. This is the first example of N-aryl-derivatives of the 4H-1,4-benzothiazine nucleus; the key step is the cyclization of N-aryl-phenylsulfonyl-acrylates 4-8 using potassium carbonate in acetonitrile/18-crown-6-ether to the corresponding title compounds in moderate yields.

Full text of DOI:10.1080/10426509808045484

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Phosphorus, Sulfur, and Silicon
and the Related Elements
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SYNTHESIS OF N-ARYL
SUBSTITUTED 4H-1,4-
BENZOTHIAZINE 1,1-DIOXIDE 2-
CARBOXYLIC ACID-ESTERS
Simon E. Lopez a , Jaime Charris b , Neudo Urdaneta
a & Gricela Lobo b
a Laboratorio de Química Orgánica 210, piso 2,
Departamento de Química , Universidad Simón
Bolívar , Valle de Sartenejas, Caracas 1080-A,
Apartado, 89000, Venezuela
b Laboratorio de Síntesis Orgánica, piso 1, Facultad
de Farmacia , Universidad Central de Venezuela ,
Caracas, 1051, Venezuela
Published online: 04 Oct 2006.
To cite this article: Simon E. Lopez , Jaime Charris , Neudo Urdaneta & Gricela Lobo
(1998) SYNTHESIS OF N-ARYL SUBSTITUTED 4H-1,4-BENZOTHIAZINE 1,1-DIOXIDE 2-
CARBOXYLIC ACID-ESTERS, Phosphorus, Sulfur, and Silicon and the Related Elements,
143:1, 53-61, DOI: 10.1080/10426509808045484
To link to this article: http://dx.doi.org/10.1080/10426509808045484
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