Synthesis and ribonuclease H related biochemical properties of α-anomeric 2'-deoxypyrimidine homooligomer and its phosphorothioate analog

DOI: 10.1016/0960-894X(96)00328-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1843 - 1848 (1996)

Update date:2022-08-03

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Authors:

Shinozuka, Kazuo

Yamada, Nobuaki

Nakamura, Akiko

Ozaki, Hiroaki

Sawai, Hiroaki

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Article abstract of DOI:10.1016/0960-894X(96)00328-9

Rnase H mediated degradation of RNA on the β-DNA·RNA duplex was inhibited by the presence of extra 2'-deoxypyrimidine homooligomer. The effect was dependent on the nature of the nucleobase, glycoside bond configuration, and the internucleotide linkage of the extra homooligomer used. Thus, α-anomeric 2'-deoxycytidylate phosphorothioate exhibited the most potent inhibitory effect (> 40%) on RNase H.

Full text of DOI:10.1016/0960-894X(96)00328-9

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