Bioorganic and Medicinal Chemistry Letters p. 1843 - 1848 (1996)
Update date:2022-08-03
Topics:
Shinozuka, Kazuo
Yamada, Nobuaki
Nakamura, Akiko
Ozaki, Hiroaki
Sawai, Hiroaki
Rnase H mediated degradation of RNA on the β-DNA·RNA duplex was inhibited by the presence of extra 2'-deoxypyrimidine homooligomer. The effect was dependent on the nature of the nucleobase, glycoside bond configuration, and the internucleotide linkage of the extra homooligomer used. Thus, α-anomeric 2'-deoxycytidylate phosphorothioate exhibited the most potent inhibitory effect (> 40%) on RNase H.
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