Chemistry of Heterocyclic Compounds p. 1218 - 1221 (1987)
Update date:2022-08-04
Topics:
Krasnov, K. A.
Slesarev, V. I.
Zakharov, A.P.
Grigor'eva, E. G.
Methylation of barbituric acid and its N-methylderivatives by diazomethane in ethers and methanol occurs only at the oxygen atom of the β-dicarbonyl fragment.The resulting 6-methoxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidine and its derivatives are methylated at both the oxygen and nitrogen atoms; relative to ethers, methanol facilitates a greater degree of methylation at the nitrogen atom.
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Doi:10.1139/v88-009
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(1987)
