Bioorganic and Medicinal Chemistry Letters p. 93 - 98 (2005)
Update date:2022-08-05
Topics:
Bruncko, Milan
McClellan, William J.
Wendt, Michael D.
Sauer, Daryl R.
Geyer, Andrew
Dalton, Christopher R.
Kaminski, Michele A.
Weitzberg, Moshe
Gong, Jane
Dellaria, Joseph F.
Mantei, Robert
Zhao, Xumiao
Nienaber, Vicki L.
Stewart, Kent
Klinghofer, Vered
Bouska, Jennifer
Rockway, Todd W.
Giranda, Vincent L.
A series of non-amide-linked 6-substituted-2-naphthamidine urokinase plasminogen activator (uPA) inhibitors are described. These compounds possess excellent binding activities and selectivities with significantly improved pharmacokinetic profiles versus p
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