
Journal of the Chemical Society. Perkin transactions I p. 219 - 224 (1996)
Update date:2022-08-03
Topics:
Pandey, Ganesh
Reddy, Gottimukkula Devi
Chakrabarti, Debasish
PET promoted cyclisations of 1-alkenyl-2-silyl-pyrrolidines and -piperidines 9a-d to 1-aza-bicyclo[m.n.0]alkanes have been found to be stereoselective. The five-membered ring formation gives predominantly cis products while six-membered rings are trans. Application of such cyclisations to the synthesis of (±)-isoretronecanol 22a, (±)-epilupinine 29 and related alkaloids has been demonstrated. Copyright 1996 by the Royal Society of Chemistry.
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