Propane phosphonic acid anhydride: A mild reagent for β-lactam synthesis

Article abstract of DOI:10.1080/00397910008087001

The use of propane phosphonic acid anhydride (T3P()) as an acid activating reagent was demonstrated in the syntheses of cis β-lactams from the reactions of a glycine Dane salt and various imines.

Full text of DOI:10.1080/00397910008087001

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Propane Phosphonic Acid
Anhydride: A Mild Reagent for
β-Lactam Synthesis
K. S. Crichfield a , J. E. Hart a , J. T. Lampert a & R.
K. Vaid b
a Development and Technical Services, Lilly Research
Laboratories, A Division of Eli Lilly and Company,
Clinton Laboratories, Clinton, Indiana, 47842
b Tippecanoe Laboratories, Chemical Process
Development, A Division of Eli Lilly and Company, P.
O. Box 685, Lafayette, IN, 47905
Version of record first published: 04 Dec 2007.
To cite this article: K. S. Crichfield, J. E. Hart, J. T. Lampert & R. K. Vaid (2000):
Propane Phosphonic Acid Anhydride: A Mild Reagent for β-Lactam Synthesis, Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 30:20, 3737-3744
To link to this article: http://dx.doi.org/10.1080/00397910008087001
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