Angewandte
Chemie
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[12] a) H. Torii, M. Nakadai, K. Ishihara, S. Saito, H. Yamamoto,
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[13] Nornicotine was reported to promote the aldol reaction in water,
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[15] The absolute configuration of the anti isomer was determined by
comparison of the optical rotation with that reported in the
literature: S. E. Denmark, R. A. Stavenger, K.-T. Wong, X. Su, J.
Am. Chem. Soc. 1999, 121, 4982.
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[17] The other organic solvents gave poor results.
[18] In some reactions,[12] the ee value was increased in the presence
of water.
[19] D. Enders, C. Grondal, Angew. Chem. 2005, 117, 1235; Angew.
Chem. Int. Ed. 2005, 44, 1210.
[20] The reaction could be also performed on a 70-mmol scale.
Angew. Chem. Int. Ed. 2006, 45, 958 –961ꢀ 2006 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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