Bioorganic and Medicinal Chemistry Letters p. 2823 - 2827 (2004)
Update date:2022-08-03
Topics:
Peukert, Stefan
Brendel, Joachim
Pirard, Bernard
Struebing, Carsten
Kleemann, Heinz-Werner
Boehme, Thomas
Hemmerle, Horst
The search for novel, potent Kv1.5 blockers based on an anthranilic amide scaffold employing a pharmacophore-based virtual screening approach is described. The synthesis and structure-activity relationships (SAR) with respect to inhibition of the Kv1.5 ch
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