Bioorganic and Medicinal Chemistry Letters p. 4501 - 4505 (2013)
Update date:2022-08-03
Topics:
Gangloff, Anthony R.
Brown, Jason
De Jong, Ron
Dougan, Douglas R.
Grimshaw, Charles E.
Hixon, Mark
Jennings, Andy
Kamran, Ruhi
Kiryanov, Andre
O'Connell, Shawn
Taylor, Ewan
Vu, Phong
Structure based drug design of a series of novel 1,4-benzoxazin-3-one derived PARP-1 inhibitors are described. The synthesis, enzymatic & cellular activities and pharmacodynamic effects are described. Optimized analogs demonstrated inhibition of poly-ADP-ribosylation in SW620 tumor bearing nude mice through 24 h following a single dose.
View MoreTaizhou Elitechemie MediPharma Technology Co.,Ltd.
Contact:+86-523-86810021
Address:Building G14,NO.1 Avenue,China Medical City, Taizhou, Jiangsu,China
CHANGZHOU HANGYU PHARMACEUTICAL TECHNOLOGY CO., LTD
website:http://www.czyys.com
Contact:0086-519-88802789
Address:No.300,Yanling Middle Road, Changzhou, Jiangsu, China
WUXI KINGHAN BIO-MEDICAL&CHEMICAL INC.
Contact:13861062998
Address:Room 1316,No.1619 Huishan Avenue,Wuxi,China
Zhejiang Genebest Pharmaceutical Co.,Ltd.
Contact:0086-571-63532866
Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Shanghai Forever Biotech Co., Ltd.
Contact:+86-21-69734790
Address:Room 5017/5019、5022、5024 of Technology Innovation Centre, No.1155, Gongyuan East Rd, QingPu District, Shanghai China.
Doi:10.1021/jo026295b
(2002)Doi:10.1016/S0040-4039(02)01831-2
(2002)Doi:10.1021/ja012518o
(2002)Doi:10.1016/0040-4020(73)80249-2
(1973)Doi:10.3390/molecules22111925
(2017)Doi:10.1021/ja01161a051
(1950)