Structure activity relationships in reactivators of organophosphorus inhibited acetylcholinesterase. VII. 1 Aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides

Article abstract of DOI:10.1021/jm00247a005

A series of 1 aryl 2 hydroxyiminomethyl 3 methylimidazolium iodides, where the aryl group is either phenyl or substituted phenyl, was prepared and tested for their reactivating potency on phosphorylated acetylcholinesterase (AChE) and for anti AChE activity. The in vitro testing revealed that some of the new compounds are good reactivators. Correlations between their structure and biological activities have been attempted.