Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5- b]pyridazines for the Treatment of Human African Trypanosomiasis

DOI: 10.1021/acs.jmedchem.9b01741

Source and publish data:

Journal of Medicinal Chemistry p. 756 - 783 (2020)

Update date:2022-08-15

Topics:

Authors:

Tear, Westley F.

Bag, Seema

Diaz-Gonzalez, Rosario

Ceballos-Pérez, Gloria

Rojas-Barros, Domingo I.

Cordon-Obras, Carlos

Pérez-Moreno, Guiomar

García-Hernández, Raquel

Martinez-Martinez, Maria Santos

Ruiz-Perez, Luis Miguel

Gamarro, Francisco

Gonzalez Pacanowska, Dolores

Caffrey, Conor R.

Ferrins, Lori

Manzano, Pilar

Navarro, Miguel

Pollastri, Michael P.

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Article abstract of DOI:10.1021/acs.jmedchem.9b01741

From a high-throughput screen of 42 44 known human kinases inhibitors, a pyrazolo[1,5-b]pyridazine scaffold was identified to begin optimization for the treatment of human African trypanosomiasis. Previously reported data for analogous compounds against h

Full text of DOI:10.1021/acs.jmedchem.9b01741

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Product name:2-Pyrimidinamine, N-(3-nitrophenyl)-4-pyrazolo[1,5-b]pyridazin-3-yl-

Cas No:551919-69-8

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