Design, synthesis, and structure-activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis

Article abstract of DOI:10.1016/j.bmcl.2005.06.100

A series of podocarpic acid amides were identified as potent agonists for Liver X receptor α and β subtypes, which are members of a nuclear hormone receptor superfamily that are involved in the regulation of a variety of metabolic pathways including chole