Utilization of a β-aminophosphotyrosyl mimetic in the design and synthesis of macrocyclic Grb2 SH2 domain-binding peptides

DOI: 10.1021/jm030049q

Source and publish data:

Journal of Medicinal Chemistry p. 2621 - 2630 (2003)

Update date:2022-08-04

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Authors:

Lee, Kyeong

Zhang, Manchao

Liu, Hongpeng

Yang, Dajun

Burke Jr., Terrence R.

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Article abstract of DOI:10.1021/jm030049q

Grb2 SH2 domains are protein-docking modules that exert important functions in both normal and pathogenic signal transduction processes. Development of synthetic Grb2 SH2 domain binding ligands is being pursued by several groups as potential new therapies

Full text of DOI:10.1021/jm030049q

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