191. Synthesis of Urinary Metabolites of Retinoic Acid

Article abstract of DOI:10.1002/hlca.19830660705

Urinary metabolites 5-methyl-5-<2-(2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-vinyl>-2-tetrahydrofuranone (1) and 5-<2-(6-hydroxymethyl-2,6-dimethyl-3-oxo-1-cyclohexen-1-yl)vinyl>-5-methyl-2-tetrahydrofuranone (2) of retinoic acid have been synthesized from 4-<2,2,6-trimethyl-3-(tetrahydro-2H-pyran-2-yl)oxy-1-cyclohexen-1-yl>-3-buten-2-one (4) and methyl 2-(3,3-ethylenedioxy-1-butenyl)-1,3-dimethyl-4-oxo-2-cyclohexene-1-carboxylate (5).