Bioorganic and Medicinal Chemistry Letters p. 2163 - 2167 (2005)
Update date:2022-08-03
Topics:
Thompson, Christopher F.
Quraishi, Nazia
Ali, Amjad
Tata, James R.
Hammond, Milton L.
Balkovec, James M.
Einstein, Monica
Ge, Lan
Harris, Georgianna
Kelly, Theresa M.
Mazur, Paul
Pandit, Shilpa
Santoro, Joseph
Sitlani, Ayesha
Wang, Chuanlin
Williamson, Joanne
Miller, Douglas K.
Yamin, Ting-Ting D.
Thompson, Chris M.
O'Neill, Edward A.
Zaller, Dennis
Forrest, Michael J.
Carballo-Jane, Ester
Luell, Silvi
A series of novel ligands for the glucocorticoid receptor containing two heterocycles were synthesized. These compounds were investigated for a dissociative profile using transrepression and transactivation assays. Several compounds were tested in vivo and showed the ability to reduce inflammation in a mouse.
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