Tetrahedron p. 5735 - 5740 (1994)
Update date:2022-09-26
Topics:
Chengzhi
Buechler
Lowe
Urwyler
Shapiro
The synthesis of a pyrimidine isostere 2 of the potent N-methyl-D-aspartate (NMDA) receptor antagonist SDZ EAB 515, 1, has been achieved. Suprisingly, isostere 2 is more than two orders of magnitude less active than 1.
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