Tetrahedron Letters p. 2231 - 2234 (1988)
Update date:2022-07-30
Topics:
Bailey, Patrick D.
Bryans, Justin S.
A stereo- and enantio-specific synthesis of the naturally occuring cis-5-hydroxy-(L)-pipecolic acid (3) is described, starting from Z-(L)-glutamic acid; the key step involves cyclisation of a protected chlorohydrin, and also gives access to trans-5-hydroxy-(L)-pipecolic acid.
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