Archiv der Pharmazie p. 688 - 690 (1983)
Update date:2022-08-05
Topics:
Kairisalo
Honkanen
A simple and economical synthesis of cimetidine is described. It is based on the reaction of 4-halomethyl-5-methylimidazole with N-cyano-N'-methyl-N''-(2 mercaptoethyl)guanidine in water-ethanol at pH 9.0 ± 0.3. Pure crystalline cimetidine is obtained in about 75% yield.
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()Doi:10.1021/ja01625a064
(1955)
