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Synthesis of cimetidine

DOI: 10.1002/ardp.19833160807

Source and publish data:

Archiv der Pharmazie p. 688 - 690 (1983)

Update date:2022-08-05

Topics:

Authors:

KairisaloKairisalo

HonkanenHonkanen

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Article abstract of DOI:10.1002/ardp.19833160807

A simple and economical synthesis of cimetidine is described. It is based on the reaction of 4-halomethyl-5-methylimidazole with N-cyano-N'-methyl-N''-(2 mercaptoethyl)guanidine in water-ethanol at pH 9.0 ± 0.3. Pure crystalline cimetidine is obtained in about 75% yield.

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Full text of DOI:10.1002/ardp.19833160807

Products guided by the article

Product name:1H-Imidazole, 4-(bromomethyl)-5-methyl-, monohydrobromide

Cas No:66187-97-1

66187-97-1

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