Probing enzyme stereospecificity. Evaluation of β-alkoxy-α-amino acids with two stereocenters as inhibitors of serine proteases

Article abstract of DOI:10.1016/0040-4020(95)00382-I

L-N-Acetyl-O-(arylalkyl)-serines incorporating two stereocenters were prepared via ring-opening reactions of an aziridine precursor, derived from L-serine, with each of R and S 1-phenyl- and 2-methoxy-3-phenylethanol. These were then evaluated as inhibito