New compounds: Peptide derivatives of the antitumor agent N-phosphonoacetyl-L-aspartic acid

Article abstract of DOI:10.1002/jps.2600730237

Two peptide forms of the antitumor transition state analogue N-phosphonoacetyl-L-aspartic acid (N²-phosphonoacetyl-N⁴-glycylglycinamidoethyl-L-asparagine and N¹-glycylglycinamidoethyl-N²-phosphonoacetyl-L-isoasparagine) have been synthesized to obtain potential medicinal agents useful as prodrugs or in a lysosomotropic carrier approach. The bridging unit, ethylenediamine, used for synthetic purposes might be of general interest.