A Thiol-Containing Ester Side Chain in a Sesquiterpene Lactone from Eupatorium mikanioides. Absolute Configuration of Deacetyleupaserrin and Its Congeners

DOI: 10.1021/jo01291a023

Source and publish data:

Journal of Organic Chemistry p. 489 - 493 (1980)

Update date:2022-08-04

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Authors:

Herz, Werner

Kumar, Narendra

Blount, John F.

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Article abstract of DOI:10.1021/jo01291a023

Extraction of Eupatorium mikanioides Chapm. yielded a group of 2-hydroxy-8-(acyloxy)-trans,trans-1-(10),4-germacradienolides related to the antileukemic sesquiterpene lactone deacetyleupaserrin (1c) which was also isolated.Absolute configurations were established by X-ray crystallography of one of the constituents (1e) which had an unprecedented thiol-containing ester side chain.The flavone eupatorin was also isolated.

Full text of DOI:10.1021/jo01291a023

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