STEREOCHEMICAL ASPECTS OF THE REACTION OF DIALKYL PHOSPHATES WITH AMINE IN THE PRESENCE OF TRIPHENYLPHOSPHINE AND CARBON TETRACHLORIDE

Article abstract of DOI:10.1016/S0040-4039(00)98740-9

Activation of P-chiral dialkyl phosphates with triphenylphosphine-carbon tetrachloride involves intermediate phosphonium salt 1 which undergoes nucleophilic attack by aniline or pyridine with inversion of configuration at the chiral phosphorus atom.