Cleavage of esters using carbonates and bicarbonates of alkali metals: Synthesis of thymopentin

Article abstract of DOI:10.1016/S0040-4039(00)92619-4

A novel method for hydrolysis of primary esters using aqueous alkali carbonates or bicarbonates and an alcohol as cosolvent is described. Several peptide esters, including a Cbz-Arg-Lys(Cbz)-Asp(OBzl)-Val-Tyr-OBzl (sequence corresponding to the active site of thymic immunoregulatory hormone, thymopoietin), were hydrolyzed to demonstrate the utility of this method.