Cleavage of esters using carbonates and bicarbonates of alkali metals: Synthesis of thymopentin

DOI: 10.1016/S0040-4039(00)92619-4

Source and publish data:

Tetrahedron Letters p. 327 - 330 (1991)

Update date:2022-08-05

Topics:

Authors:

Kaestle Kaestle

Anwer Anwer

Audhya Audhya

Goldstein

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Article abstract of DOI:10.1016/S0040-4039(00)92619-4

A novel method for hydrolysis of primary esters using aqueous alkali carbonates or bicarbonates and an alcohol as cosolvent is described. Several peptide esters, including a Cbz-Arg-Lys(Cbz)-Asp(OBzl)-Val-Tyr-OBzl (sequence corresponding to the active site of thymic immunoregulatory hormone, thymopoietin), were hydrolyzed to demonstrate the utility of this method.

Full text of DOI:10.1016/S0040-4039(00)92619-4

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