Synthesis and muscarinic activities of 1,2,4-thiadiazoles

Article abstract of DOI:10.1021/jm00169a041

A series of novel 1,2,4-thiadiazoles bearing a mono- or bicyclic amine at C5 were prepared. Quinuclidine and 1-azabicyclo[2.2.1]heptane derivatives were synthesized by reaction of the lithium enolate of the 3-methoxycarbonyl compounds followed by ester hy