Synthesis and muscarinic activities of 1,2,4-thiadiazoles

DOI: 10.1021/jm00169a041

Source and publish data:

Journal of Medicinal Chemistry p. 2052 - 2059 (1990)

Update date:2022-08-02

Topics:

Authors:

MacLeod MacLeod

Baker Baker

Freedman

Patel Patel

Merchant

Roe Roe

Saunders

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Article abstract of DOI:10.1021/jm00169a041

A series of novel 1,2,4-thiadiazoles bearing a mono- or bicyclic amine at C5 were prepared. Quinuclidine and 1-azabicyclo[2.2.1]heptane derivatives were synthesized by reaction of the lithium enolate of the 3-methoxycarbonyl compounds followed by ester hy

Full text of DOI:10.1021/jm00169a041

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