A novel synthesis of the carbapen-2-em ring system

DOI: 10.1016/S0040-4039(00)93616-5

Source and publish data:

Tetrahedron Letters p. 31 - 34 (1980)

Update date:2022-07-31

Topics:

Authors:

Ratcliffe

Salzmann

Christensen

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Article abstract of DOI:10.1016/S0040-4039(00)93616-5

A new synthesis of the carbapenem ring system, as found in thienamycin and related natural products, has been developed. The key step involves a highly efficient carbene insertion reaction which produces the bicyclic ring system by forming the N3 bond.

Full text of DOI:10.1016/S0040-4039(00)93616-5

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