Sugar-based phosphite and phosphoroamidite ligands for the Cu-catalyzed asymmetric 1,4-addition to enones

Article abstract of DOI:10.1016/j.tetasy.2009.09.002

A modular sugar-based phosphoroamidite L1-L5a-g and phosphite L6-L9a-g ligand library was tested in the asymmetric Cu-catalyzed 1,4-conjugate addition reactions of β-substituted (cyclic and linear) and β,β′-disubstituted (cyclic) enones. The selectivity d