A new synthesis of n-blocked dihydrouracil and dihydroorotic acid derivatives using lithium tri-sec-butyl borohydride as reducing agent

Article abstract of DOI:10.1016/S0040-4039(01)83925-3

1,3-Di-N-substituted uracil and its derivatives have been reduced with lithium-tri-sec-butyl borohydride to the corresponding 5,6-dihydro compounds in excellent yields. Alkylation of 5-position of uracil is also very conveniently accomplished.