Synthesis of analogues of the carboxyl protease inhibitor pepstatin. Effect of structure on inhibition of pepsin and renin

DOI: 10.1021/jm00175a006

Source and publish data:

Journal of Medicinal Chemistry p. 27 - 33 (1980)

Update date:2022-09-26

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Authors:

Rich Rich

Sun Sun

Ulm Ulm

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Article abstract of DOI:10.1021/jm00175a006

Analogues of the carboxyl protease inhibitor, pepstatin, were synthesized from optically pure forms of N-(tert-butoxycarbonyl)-4-amino-3-hydroxy-6-methylheptanoic acid (Boc-Sta), and the inhibition of pepsin and renin was determined. In addition, the new

Full text of DOI:10.1021/jm00175a006

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