Aporphines. 35. Synthesis of (R)-(-)- and (S)-(+)-Apomorphine from Thebaine and (+)-Bulbocapnine

Article abstract of DOI:10.1021/jo00326a058

A practical method for the synthesis of (-)-apomorphine and (-)-N-n-propylnorapomorphine from the opioid thebaine is presented.The method is also applicable to the transformation of (+)-bulbocapnine to (+)-apomorphine.