248. Iodine Oxidation of S-Trityl- and S-Acetamidomethyl-cysteine-peptides Containing Tryptophan: Conditions Leading to the Formation of Tryptophan-2-thioethers

Article abstract of DOI:10.1002/hlca.19800630826

Cystine peptides are conveniently prepared from S-acetamidomethyl- or S-trityl-protected cysteine derivatives by direct oxidation with iodine.Since the reaction proceeds through the formation of sulfenyl iodides, these highly reactive goups may substitute