The synthesis and evaluation of 6-alkylidene-2'β-substituted penam sulfones as β-lactamase inhibitors

DOI: 10.1016/S0960-894X(99)00325-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1997 - 2002 (1999)

Update date:2022-08-05

Topics:

Authors:

Buynak, John D.

A Srinivasa, Rao

Doppalapudi, Venkata Ramana

Adam, Greg

Petersen, Peter J.

Nidamarthy, Sirishkumar D.

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Article abstract of DOI:10.1016/S0960-894X(99)00325-X

Penicillin sulfones, which structurally incorporate both a 6-position alkylidene substituent and a 2'β substituent, have been synthesized and evaluated as inhibitors of class C and class A serine β-lactamases. Incorporation of the 2'β-substituent generall

Full text of DOI:10.1016/S0960-894X(99)00325-X

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