Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4'-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline

Article abstract of DOI:10.1016/0040-4020(96)00649-7

A new strategy for the synthesis of oxide-containing fragments of morphine has been developed. Thus, the tricyclic (ANO) morphine fragment spiro[7-methoxybenzofuran-3(2H),4'-1'-methylpiperidine] (1) was obtained as the sole product via an intramolecular r